Anti-CCL3 (MIP-1α) antibodies, human

Anti-CCL3 (MIP-1α) antibodies, human

Clone: REA257 | Dilution: 1:10
Clone REA257 recognizes the C-C motif chemokine 3 (CCL3) antigen also known as macrophage inflammatory protein 1 alpha (MIP-1α). CCL3 is a cytokine belonging to the members of the β (CC) subfamily of chemokines. It is produced by T cells, B cells, Langerhans cells, neutrophils, and macrophages. CCL3 is involved in activation and recruitment of lymphocytes, monocytes, and granulocytes during acute inflammation and plays a role as a chemoattractant of monocytes, B cells, eosinophils, and cytotoxic T cells. It has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells
in vitro
as well as
in vivo
. Moreover, CCL3 has been reported to be involved in susceptibility of HIV infection and disease progression of AIDS. The functional receptor for CCL3 has been identified as CCR1 and CCR5.
Additional information: Clone REA257 displays negligible binding to Fc receptors.

Alternative Names

G0S19-1, LD78alpha, MIP-1-alpha, MIP1A, Scya3, tonsillar lymphocyte LD78 alpha protein

Technical specifications

  • Antigen: CCL3 (MIP-1α)
  • Clone: REA257
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: G0S19-1, LD78alpha, MIP-1-alpha, MIP1A, Scya3, tonsillar lymphocyte LD78 alpha protein
  • Entrez Gene ID: 6348
  • Molecular mass of antigen [kDa]: 8
  • Distribution of antigen: B cells, T cells, macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770
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