Anti-Carbonic Anhydrase 9 antibodies, human

Anti-Carbonic Anhydrase 9 antibodies, human

Clone: REA658 | Dilution: 1:11
Clone REA658 recognizes the human carbonic anhydrase IX, a single-pass type I integral membrane protein detected in HeLa cells and in different human carcinomas. This tumor-associated isoenzyme is also expressed on the surface microvilli and in the nucleus. Carbonic anhydrase IX, also known as CAIX, CA9, or MN, is a member of the alpha-carbonic anhydrase family that catalyze the reversible hydration of carbon dioxide. It may plays a role in the control of cell proliferation and transformation and seems to be a novel specific biomarker for identifying cervical dysplasia and carcinoma. Carbonic anhydrases participate in a variety of biological processes.
Additional information: Clone REA658 displays negligible binding to Fc receptors.

Alternative Names

Carbonic anhydrase IX, CA9, CAIX, CA-IX, MN

Technical specifications

  • Antigen: Carbonic Anhydrase 9
  • Clone: REA658
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Carbonic anhydrase IX, CA9, CAIX, CA-IX, MN
  • Entrez Gene ID: 768
  • Molecular mass of antigen [kDa]: 46
  • Distribution of antigen: cancer cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected References

    1. Pastorek, J. et al. (1994) Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. Oncogene 9(10): 2877-2888
    2. Opavsky, R. et al. (1996) Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. Genomics 33(3): 480-487
Product options: 6
130-110-091

Anti-Carbonic Anhydrase 9-PE, human

for 30
tests
(1)
-
130-110-057

Anti-Carbonic Anhydrase 9-PE, human

for 100
tests
(1)
-
130-110-092

Anti-Carbonic Anhydrase 9-APC, human

for 30
tests
(1)
-
130-110-058

Anti-Carbonic Anhydrase 9-APC, human

for 100
tests
(1)
-
130-110-090

Anti-Carbonic Anhydrase 9-Biotin, human

for 30
tests
(1)
-
130-110-056

Anti-Carbonic Anhydrase 9-Biotin, human

for 100
tests
(1)
-