Anti-C3a Receptor antibodies, human

Anti-C3a Receptor antibodies, human

Clone: hC3aRZ8 | Dilution: 1:11
Clone hC3aRZ8 recognizes the human C3a anaphylatoxin chemotactic receptor (C3aR) antigen, a 54 kDa seven transmembrane GTP-binding-protein–coupled receptor which belongs to the rhodopsin supergene family. C3aR is expressed by various cells, including cells of hematopoietic origin such as neutrophils and monocytes, but also non-hematopoietic cells such as renal proximal tubular epithelial cells or neural cells. C3aR functions as a cell surface receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, a C-terminal 77 amino acid cleavage product of the alpha chain of C3. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3aR. After C3a binding, the C3aR signaling results in chemotaxis, granule enzyme release, and superoxide anion production. C3aR binding on T cells promotes CD4
+
and CD8
+
T cell activation, proliferation, differentiation, and survival, independently of TCR signals.

Alternative Names

C3AR1, AZ3B, C3AR, HNFAG09

Technical specifications

  • Antigen: C3a Receptor
  • Clone: hC3aRZ8
  • Isotype: mouse IgG2b
  • Isotype control: Mouse IgG2b – isotype control antibodies
  • Alternative names of antigen: C3AR1, AZ3B, C3AR, HNFAG09
  • Entrez Gene ID: 719
  • Molecular mass of antigen [kDa]: 54
  • Distribution of antigen: neutrophils, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected References

    1. Ames, R. S. et al. (1996) Molecular cloning and characterization of the human anaphylatoxin C3a receptor. J. Biol. Chem. 271(34): 20231-20234
    2. Crass, T. et al. (1996) Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. Eur. J. Immunol. 26(8): 1944-1950
    3. Gao, J. et al. (2003) Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. J. Biol. Chem. 278(39): 37902-37908
Product options: 10
130-108-108

Anti-C3a Receptor-FITC, human

for 30
tests
(1)
-
130-108-073

Anti-C3a Receptor-FITC, human

for 100
tests
(1)
-
130-108-109

Anti-C3a Receptor-PE, human

for 30
tests
(1)
-
130-108-074

Anti-C3a Receptor-PE, human

for 100
tests
(1)
-
130-108-110

Anti-C3a Receptor-APC, human

for 30
tests
(1)
-
130-108-075

Anti-C3a Receptor-APC, human

for 100
tests
(1)
-
130-108-111

Anti-C3a Receptor-PE-Vio770, human

for 30
tests
(1)
-
130-108-076

Anti-C3a Receptor-PE-Vio770, human

for 100
tests
(1)
-
130-108-194

Anti-C3a Receptor-Biotin, human

for 30
tests
(1)
-
130-108-168

Anti-C3a Receptor-Biotin, human

for 100
tests
(1)
-