Anti-Btk antibodies, human

Anti-Btk antibodies, human

Clone: REA367 | Dilution: 1:50
Clone REA367 recognizes the human bruton tyrosine kinase (Btk) antigen, a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B cell–development, –differentiation, and –signaling. Moreover, Btk expression is assumed to be a prerequisite for B cell–proliferation and –survival. Consequently, Btk-deficient B lymphocytes fail to reach the mature state and are presumably doomed to premature death. Btk is reported to be associated with human disease. Thus, individuals harboring loss-of-function mutations in the gene encoding Btk virtually lack circulating B lymphocytes, are unable to generate immunoglobulins of all classes, and therefore cannot mount humoral immune responses. This primary immunodeficiency is named X-linked agammaglobulinemia.
Additional information: Clone REA367 displays negligible binding to Fc receptors.

Alternative Names

AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA

Technical specifications

  • Antigen: Btk
  • Clone: REA367
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA
  • Entrez Gene ID: 695
  • Molecular mass of antigen [kDa]: 76
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
Product options: 2

Product information

Size
Order no.
Price

Anti-Btk-PE, human

  • REA367
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-669
-

Anti-Btk-PE, human

  • REA367
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-524
-

Related products

3 products available