Anti-BLNK pY84 antibodies, human and mouse

Anti-BLNK pY84 antibodies, human and mouse

Clone: REA240 | Dilution: 1:10
Clone REA240 recognizes BLNK protein phosphorylated at tyrosine 84. BLNK is an approximately 50 KDa src homology 2 and 3 domain–containing protein that bears homology to another adaptor molecule called SLP-76 and serves as a central linker/adaptor protein involved in bridging B cell receptor–associated kinase activation with downstream signaling pathways. BLNK is phosphorylated upon BCR stimulation and couples protein tyrosine kinase (PTK) Syk activation to downstream components such as Grb2, Vav, Nck, and phospholipase C (PLC)-γ2. Further, BLNK has been shown to play a role in the activation of all three classes of mitogen-activated protein kinases (MAPKs). Expression of BLNK is found in B cell lineage cells.
Additional information: Clone REA240 displays negligible binding to Fc receptors.

Alternative names

AGM4, BASH, BLNK-S, SLP65, bca, Ly-57, Lyw-57

Technical specifications

  • Antigen: BLNK pY84
  • Clone: REA240
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: AGM4, BASH, BLNK-S, SLP65, bca, Ly-57, Lyw-57
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Baba, Y. et al. (2001) BLNK mediates Syk-dependent Btk activation. Proc. Natl. Acad. Sci. U.S.A. 98: 2582-2586
    2. Wong, J. et al. (2000) Functional complementation of BLNK by SLP-76 and LAT linker proteins. J. Biol. Chem. 275: 33116-33122
    3. Kabak, S. et al. (2002) The direct recruitment of BLNK to immunoglobulin couples the B-cell antigen receptor to distal signaling pathways. Mol. Cell. Biol. 22: 2524-2535
Product options: 6
130-101-497

Anti-BLNK pY84-PE, human and mouse

for 30
tests
(1)
-
130-101-496

Anti-BLNK pY84-PE, human and mouse

for 100
tests
(1)
-
130-101-492

Anti-BLNK pY84-APC, human and mouse

for 30
tests
(1)
-
130-101-485

Anti-BLNK pY84-APC, human and mouse

for 100
tests
(1)
-
130-101-501

Anti-BLNK pY84-PE-Vio770, human and mouse

for 30
tests
(1)
-
130-101-500

Anti-BLNK pY84-PE-Vio770, human and mouse

for 100
tests
(1)
-