Anti-BATF antibodies, human

Anti-BATF antibodies, human

Clone: REA486 | Dilution: 1:11
Clone REA486 recognizes the human B cell–activating transcription factor (BATF) antigen, a 14 kDa transcription factor belonging to the AP-1 family of basic leucine zipper transcription factors. BATF plays an important role in regulating differentiation and function in many lymphocyte lineages. In the CD8
+
T cell lineage, increased expression of BATF in exhausted CD8
+
T cells suppresses their effector function. In the CD4
+
T cell lineage, BATF is required for the differentiation of interleukin 17 producing helper T cells, where it binds cooperatively with the transcription factor IRF4 and its dimerization partners c-Jun, JunB, and JunD. BATF is also important for the development of follicular helper T cells by regulating the transcription factors Bcl-6 and c-Maf. In addition, BATF is required for class-switch recombination in B cells and to regulate activation-induced cytidine deaminase as well as DNA damage checkpoint in hematopoietic stem cell self-renewal.
Additional information: Clone REA486 displays negligible binding to Fc receptors.

Alternative Names

B-ATF1, SFA-2, SFA2, B-ATF

Technical specifications

  • Antigen: BATF
  • Clone: REA486
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: B-ATF1, SFA-2, SFA2, B-ATF
  • Entrez Gene ID: 10538
  • Molecular mass of antigen [kDa]: 14
  • Distribution of antigen: B cells, leukocytes, T cells, T helper cells, ubiquitous, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
Product options: 6

Product information

Size
Order no.
Price

Anti-BATF-FITC, human

  • REA486
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-662
-

Anti-BATF-FITC, human

  • REA486
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-618
-

Anti-BATF-PE, human

  • REA486
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-663
-

Anti-BATF-PE, human

  • REA486
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-619
-

Anti-BATF-APC, human

  • REA486
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-664
-

Anti-BATF-APC, human

  • REA486
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-620
-

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