Anti-AN2 antibodies, human and mouse

Anti-AN2 antibodies, human and mouse

Clone: REA989 | Dilution: 1:50
Clone REA989 recognizes the human and mouse AN2 antigen. AN2 is the mouse homolog of the rat NG2 and human MCSP proteins. NG2 is a chondroitin sulfate glycoprotein that is expressed by glial progenitor cells in the developing and adult central nervous system (CNS) and by immature Schwann cells. NG2/AN2
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glia has been identified as a fourth major glial cell type in the mammalian CNS that is distinct from other cell types. NG2/AN2
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cells are precursors of oligodendrocytes and some protoplasmic astrocytes in the gray matter. NG2/AN2 expression is down-regulated before the cells undergo terminal differentiation. However, a population of NG2/AN2
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cells remains in the white and gray matter after oligodendrocytes are generated. NG2/AN2
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glial cells participate in neuron-glial circuits by receiving presynaptic input from neurons and responding to neurotransmitters released by synapses. Many highly migratory neural tumors including melanomas express NG2/AN2.
Additional information: Clone REA989 displays negligible binding to Fc receptors.

Alternative Names

CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Technical specifications

  • Antigen: AN2
  • Clone: REA989
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
  • Entrez Gene ID: 1464
  • Molecular mass of antigen [kDa]: 248
  • Distribution of antigen: Schwann cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBright 515, Biotin

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