Anti-AKT1 antibodies, human

Anti-AKT1 antibodies, human

Clone: REA134 | Dilution: 1:11
Clone REA134 recognizes AKT1, which is also known as protein kinase Bα. AKT1 is a serine/threonine protein kinase, belonging to the AKT family of kinases and like each AKT family member, contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a carboxyl-terminal regulatory domain with a hydrophobic motif (HM). Activation of AKT1 is achieved via phosphorylation at multiple sites, which take place in response to engagement of receptors such as platelet derived growth factor receptor (PDGF-R). Activated AKT1 further phosphorylates and alters the activity of several downstream substrates allowing AKT1 to play a vital role in various biological processes such as cell growth, survival, migration, and proliferation.
Additional information: Clone REA134 displays negligible binding to Fc receptors.

Alternative names

AKT, CWS6, PKB, PRKBA, RAC, RAC-ALPHA, PKBα

Technical specifications

  • Antigen: AKT1
  • Clone: REA134
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: AKT, CWS6, PKB, PRKBA, RAC, RAC-ALPHA, PKBα
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
  • Selected references

    1. Calamito, M. et al. (2010) Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood 115: 4043-4050
    2. Arranz, A. et al. (2012) Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc. Natl. Acad. Sci. U.S.A. 109(24): 9517-9522
Product options: 8
130-099-478

Anti-AKT1-PE, human

for 30
tests
(1)
-
130-099-477

Anti-AKT1-PE, human

for 100
tests
(1)
-
130-099-475

Anti-AKT1-APC, human

for 30
tests
(1)
-
130-099-476

Anti-AKT1-APC, human

for 100
tests
(1)
-
130-100-750

Anti-AKT1-PE-Vio770, human

for 30
tests
(1)
-
130-100-753

Anti-AKT1-PE-Vio770, human

for 100
tests
(1)
-
130-100-744

Anti-AKT1-PerCP-Vio700, human

for 30
tests
(1)
-
130-100-741

Anti-AKT1-PerCP-Vio700, human

for 100
tests
(1)
-