Anti-MHC Class II (OX6) MicroBeads, rat

Anti-MHC Class II (OX6) MicroBeads, rat

Anti-MHC Class II (OX6) MicroBeads have been developed for the positive selection or depletion of rat cells expressing the major histocompatibility complex (MHC) class II.

Background information

The monoclonal antibody recognizes a non-polymorphic determinant of the MHC class II antigen RT1B, the rat homolog of the murine I-A antigen. MHC class II (RT1B) is expressed on antigen-presenting cells (APCs), notably on B cells, dendritic cells, and on most monocytes and macrophages where it is up-regulated upon activation. After activation, epithelial cells, endothelial cells as well as microglia and NK cells also become MHC class II
+
.

Downstream applications

Isolated MHC class II
+
cells can be used for functional assays on antigen presentation and T cell stimulation. Additionally, Anti‑MHC Class II MicroBeads can be used for the enrichment of untouched T cells from lymph nodes by depletion of MHC class II
+
cells.

Columns

For positive selection: MS, LS, XS, or autoMACS
®
Columns. For depletion: LD, CS, D, or autoMACS Columns.
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