Anti-PSA-NCAM MicroBeads, human, mouse, rat

Anti-PSA-NCAM MicroBeads, human, mouse, rat

Anti-PSA-NCAM MicroBeads have been developed for the positive selection or depletion of PSA-NCAM
+
cells from tissue or cell culture.

Background information

Anti-PSA-NCAM MicroBeads recognize polysialic acid (PSA), which is linked to the extracellular domain of the neural cell adhesion molecule (NCAM, CD56).
1
PSA-NCAM, the highly polysialated form of NCAM, is predominantly expressed in embryonic and neonatal neural tissue
2
. In adult mammalian brain PSA-NCAM expression is restricted mainly to areas that retain neurogenic potential, such as the subventricular zone (SVZ)
3
and the dentate gyrus of the hippocampus.
4
PSA-NCAM is a marker for immature neuronal-committed progenitors that are permanently generated in the SVZ and migrate along a well-defined pathway, the rostral migratory stream, into the olfactory bulb where they differentiate into GABAergic and dopaminergic interneurons.
3,5
PSA-NCAM positive neuronal precursors have been isolated from rat forebrain and from mouse SVZ tissue after depletion of A2B5
+
glial progenitor cells.
6-10

Columns

For positive selection: MS, LS, or autoMACS
®
Columns. For depletion: LD or autoMACS Columns.
Product options: 2

Product information

Size
Order no.
Price

Anti-PSA-NCAM MicroBeads, human, mouse, rat - small size

  • For research use only
for 5×
10
7
total cells
130-092-981
-

Anti-PSA-NCAM MicroBeads, human, mouse, rat

  • For research use only
for 5×
10
8
total cells
130-092-966
-

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