CD146 MicroBead Kit, human

CD146 MicroBead Kit, human

The CD146 MicroBead Kit was developed for the isolation of CD146
+
cells. The kit consists of CD146 MicroBeads and FcR Blocking Reagent. The CD146 MicroBeads recognize the human CD146 antigen, also known as MUC18, MCAM, Mel-CAM, and S-Endo-1.

Background information

CD146 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and contains five extracellular immunoglobulin (Ig)-like domains.
1,2
CD146 possesses a limited tissue expression distribution, including endothelial cells, smooth muscle cells, pericytes, follicular dendritic cells, melanoma cells, and a subpopulation of activated T lymphocytes.
1,3
CD146
+
cells isolated from umbilical cord
4
, lipoaspirate
5
, dental pulp, or endometrial tissue
6
, are described to contain cells with clonogenic fibroblastic colony (CFU-F) activity and multilineage differentiation potential, which are often called mesenchymal or marrow stromal cells (MSCs).
CD146 functions as a Ca
2+
-independent cell adhesion molecule, which is involved in heterophilic cell-cell interactions
7
, and may be involved in the extravasion and/or homing of activated T cells
3
. CD146 expression in melanoma is also directly associated with tumor growth and metastasis.
7,8

Applications

The CD146 MicroBead Kit can be used for:
  • isolation of human mesenchymal stromal cells (MSCs) from lipoaspirate and other tissue sources,
  • isolation of endothelial cells and pericytes from human endothelial tissue,
  • isolation of human umbilical vein endothelial cells (HUVECs) and human umbilical cord perivascular cells (HUCPVCs)4 from umbilical cord vein.

Columns

LS or XS Columns.
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