Mouse IL-17 Secretion Assay – Cell Enrichment and Detection Kit (PE)

Mouse IL-17 Secretion Assay – Cell Enrichment and Detection Kit (PE)

The Mouse IL-17 Secretion Assay - Cell Enrichment and Detection Kit was developed for the sensitive detection as well as the enrichment of mouse IL-17A–secreting cells.

Background information

Interleukin 17 (IL-17) is a family of cytokines that play a central role in adaptive immunity as well as autoinflammatory disorders.
1
Data from several mouse models suggest that IL-17 plays a key role in the host defense against certain extracellular bacterial infections.
Recently, a new mouse T helper cell subset has been identified, which is dinstinct from Th1 and Th2 cells: IL-17–producing CD4
+
T helper (Th17) cells. Th17 cells preferentially produce IL-17A, IL-17F, IL-21, and IL-22. Receptors for IL-17 and IL-22 are expressed on various epithelial tissues, thus Th17 cells are crucial for the cross-talk between immune system and tissues.
2
It is now established that Th17 cells are responsible for driving autoimmune inflammation.
After stimulation of mouse cells, IL-17 is not only secreted by CD4
+
T cells, but also by CD8
+
T cells, γδ T cells, NK cells, and granulocytes.

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