Cardiac Progenitor Cell Isolation Kit (Sca-1), mouse

Cardiac Progenitor Cell Isolation Kit (Sca-1), mouse

The Cardiac Progenitor Cell Isolation Kit (Sca-1) has been specifically developed for the isolation of cardiac progenitor cells from mouse heart tissue.

Background information

A population of cardiac progenitor cells from the adult myocardium based on their expression of stem cell antigen-1 (Sca-1) has been identified.
These cells express most cardiogenic transcription factors but lack expression of cardiac structural genes. After treatment with 5-azacytidine, cardiac differentiation was induced in Sca-1
in vitro
. In addition, this population homed to the injured myocardium upon grafting in an ischemia/reperfusion mouse model following by cardiac differentiation and fusion to the host myocardium. The majority of Sca-1
cells in the adult mouse heart co-express the endothelial marker CD31.
It has been shown that only the CD31
but not CD31
population exhibit functional cardiomyogenic differentiation.
In conclusion, Sca-1
cells represent a distinct cardiac progenitor cell population, capable of differentiation into mature cardiomyocytes.


MS, LS, or autoMACS
  • Selected references

    1. Oh, H. et al. (2003) Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl. Acad. Sci. U.S.A. 100: 12313-12318
    2. Pfister, O. et al. (2005)
      but not CD31
      cardiac side population cells exhibit functional cardiomyogenic differentiation.
      Circ. Res. 97: 52-61
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Cardiac Progenitor Cell Isolation Kit (Sca-1), mouse

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