CD44 MicroBeads, human

CD44 MicroBeads, human

CD44 MicroBeads have been specifically designed and optimized for the isolation or depletion of CD44
+
cells from single-cell suspensions from solid tumors, including breast, pancreatic, colon, and prostate tissues or cancer cell lines.

Background information

CD44 is a marker for many types of cancer stem cells (CSC), including breast CSCs that possess higher tumorigenicity and metastatic potential
1
, colorectal
2
, pancreatic
3
, and prostate
4,5
CSCs. In addition, expression was observed in several cancers as well as on carcinoma cell lines. Here, it plays a role in cancer cell migration and matrix adhesion in response to a cellular microenvironment, thus enhancing cellular aggregation and tumor cell growth
6
. CD44 is also expressed on mesodermal cells, such as hematopoietic, fibroblastic, and glial cells.

Columns

For positive selection: LS, XS, or autoMACS
®
Columns. For depletion: LD, CS, D, or autoMACS Columns.
Note: This product is not suitable for cell separation with an MS Column.
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