ODN 2006 Control (ODN 2137)

ODN 2006 Control (ODN 2137)

CpG ODNs are widely used for activation of immune cells or induction of signalling in TLR9-expressing recombinant cell lines.
Control compounds which contain GpC dinucleotides instead of CpGs are useful to control for the CpG specificity of this effects.

Background information

TLR9 is a prominent member of the toll-like-receptor (TLR) family recognizing pathogen-associated molecular patterns. TLR9 recognizes specifically unmethylated CpG motifs in bacterial DNA leading to activation of immune cells
1,2
. These effects can be mimicked by short synthetical oligodeoxyribonucleotides (ODNs) containing unmethylated CpG motifs
3
.
Control compounds for CpG ODNs share the sequence with their stimulatory counterparts but contain GpC dinucleotides instead of the CpG motifs.

Applications

ODN 2006 Control (ODN 2137 ) can be used as a sequence control for B-class ODN 2006.
Product options: 2

Product information

Size
Order no.
Price

ODN 2006 Control (ODN 2137)

  • For research use only
200 µg
130-100-107
-

ODN 2006 Control (ODN 2137)

  • For research use only
1 mg
130-100-278
-