ODN 1982

ODN 1982

Oligodeoxyribonucleotides containing CpG motifs (CpG ODNs) are widely used for activation of immune cells, such as human PBMCs, murine splenocytes or isolated immune cells, e.g., B cells and pDCs. They also activate signalling in TLR9-expressing recombinant cell lines.
ODN 1982 is used as a control for CpG ODN, especially B-class CpG ODNs.

Background information

TLR9 is a prominent member of the toll-like-receptor (TLR) family recognizing pathogen-associated molecular patterns. TLR9 recognizes specifically unmethylated CpG motifs in bacterial DNA leading to activation of immune cells
1,2
. These effects can be mimicked by short synthetical oligodeoxyribonucleotides (ODNs) containing unmethylated CpG motifs
3
.
Control compounds for CpG ODNs share the sequence with their stimulatory counterparts but contain GpC dinucleotides instead of the CpG motifs.

Applications

ODN 1982 can be used as a control for CpG ODN, especially B-class CpG ODN.
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