ODN 2088

ODN 2088

TLR7/8/9 antagonists consist of short single-stranded oligodeoxynucleotides. They can inhibit CpG ODN-mediated activation of TLR9 and/or activation of TLR7/8.
ODN 2088 is a TLR7/8/9 antagonist. The sequence can form G-Tetrad structures.

Background information

TLR7, TLR8 and TLR9 are prominent members of the Toll-like-receptor (TLR) family recognizing pathogen-associated molecular patterns recognizing nucleic acids
. Activation of these TLRs can be inhibited by short single-stranded synthetical oligodeoxyribonucleotides (ODNs)
. Several classes of and motifs for inhibitory ODN have been identified


TLR7/8/9 Antagonists can be used to inhibit TLR7/8/9 mediated cellular responses, such as activation of immune cells, human PBMCs, murine splenocytes or isolated immune cells (e.g., B cells and pDCs).
TLR7/8/9 Antagonists can be used to inhibit signaling in TLR7/8/9-
expressing recombinant cell lines.
ODN 2088 is a widely used inhibitory ODN inhibiting TLR7, TLR8 and TLR9
. ODN 2088 forms tertiary structures (G tetrads).
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Product information

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