StemMACS™ Y27632

StemMACS™ Y27632

StemMACS™ Y27632 is a selective small molecule inhibitor of Rho-associated kinase (ROCK).

Background information

Rho-associated kinase is found in two isoforms, ROCK I (p160ROCK, ROCKβ) and ROCK II (ROCKα), both of which are inhibited by Y27632. The inhibition is reversible and competitive with respect to ATP.

Applications

Published applications for Y27632 include:
  • Improved survival of human pluripotent stem cells after dissociation into single cells, e.g. during cell passaging or cell separation1
  • Improved survival after thawing2
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