StemMACS™ Y27632

StemMACS™ Y27632

StemMACS™ Y27632 is a selective small molecule inhibitor of Rho-associated kinase (ROCK).

Background information

Rho-associated kinase is found in two isoforms, ROCK I (p160ROCK, ROCKβ) and ROCK II (ROCKα), both of which are inhibited by Y27632. The inhibition is reversible and competitive with respect to ATP.

Applications

Published applications for Y27632 include:
  • Improved survival of human pluripotent stem cells after dissociation into single cells, e.g. during cell passaging or cell separation1
  • Improved survival after thawing2
  • Selected References

    1. Watanabe, K. et al. (2007) A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25: 681-686
    2. Li, X. et al. (2009) ROCK inhibitor improves survival of cryopreserved serum/feeder-free single human embryonic stem cells. Hum. Reprod. 24: 580-589
  • Brochures and posters

Product options: 3

Product information

Size
Order no.
Price

StemMACS Y27632

  • For research use only
2 mg
130-103-922
-

StemMACS Y27632

  • For research use only
5×2 mg
130-104-169
-

StemMACS Y27632 in Solution

  • For research use only
2 mg
130-106-538
-