StemMACS™ RG108

StemMACS™ RG108

StemMACS™ RG108 is a selective small molecule inhibitor of DNA methyltransferase (DNMT).

Background information

StemMACS™ RG108 is a cell permeable and selective inhibitor of DNA methyltransferase (DNMT). RG108 is a non-nucleoside inhibitor that binds non-covalently and reversible to the active center (IC50 = 115 nM). It has been used as an epigenetic modifier that induces DNA demethylation and reactivation of silenced tumor suppressor genes. In pluripotent stem cell research, RG108 can enhance reprogramming efficiency.

Applications

Published applications for RG108 include:
  • Inhibition of DNA Methyltransferase1
  • Increase of reprogramming efficiency2
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Product information

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Order no.
Price

StemMACS RG108

  • For research use only
10 mg
130-104-464
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