Mo-DC Maturation Medium, human

Mo-DC Maturation Medium, human

Mo-DC Maturation Medium is designed for the production of mature monocyte-derived dendritic cells (Mo-DCs) from immature Mo-DCs.
Large numbers of monocyte‑derived dendritic cells (Mo-DCs) can be generated
ex vivo
from purified CD14
+
monocytes.
1–6
The Mo-DC Maturation Medium is used for the maturation of immature Mo-DCs. Immature (Mo-DCs) can be easily obtained through differentiation of monocytes with a lot-to-lot consistent, standardized protocol using the Mo-DC Differentiation Medium.
The Mo-DC Maturation Medium is based on RPMI 1640 medium and contains L-glutamine and tumor necrosis factor alpha. It is also a component of the Mo-DC Generation Toolbox I and the Mo-DC Generation Toolbox II.
  • Selected References

    1. Banchereau, J. and Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392: 245-252
    2. Sallusto, F. and Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179: 1109-1118
    3. Dauer, M. et al. (2003) Mature dendritic cells derived from human monocytes within 48 hours: a novel strategy for dendritic cell differentiation from blood precursors. J. Immunol. 170: 4069-4076
    4. Zhang, R. et al. (2006) C-reactive protein impairs human CD14+ monocyte-derived dendritic cell differentiation, maturation and function. Eur. J. Immunol. 36: 2993-3006
    5. Sanarico, N. et al. (2006) Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Tʜ1 immune response. J. Leukoc. Biol. 80: 555-562
    6. Assier, E. et al. (2007) TLR7/8 agonists impair monocyte-derived dendritic cell differentiation and maturation. J. Leukoc. Biol. 81: 221-228
Product options: 1

Product information

Size
Order no.
Price

Mo-DC Maturation Medium, human

  • For research use only
100 mL
130-094-813
-