Rat IL-4

Rat IL-4

IL-4 stands for interleukin 4. Rat IL-4 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Rat IL-4 can be used for a variety of applications, including:
  • In vitro differentiation of naive CD4+ T cells towards Tʜ2 cells.
  • In vitro studies of bone marrow precursor development to DCs, together with GM-CSF.

Background information

IL-4 is produced mainly by activated TH2 cells and, to a lesser extent, by Tʜ1 cells. It binds to the IL-4 receptor α (CD124), followed by the dimerization with other receptor chains to generate type 1 and type 2 receptors. IL-4 promotes the proliferation and differentiation of activated B cells and the expression of MHC class II antigens. Mature rat IL-4 shares 59% aa sequence identity with mouse IL-4.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of Con-A–activated rat spleen cells
  • research grade: ≥ 5×
    10
    5
    U/mg
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