Mouse TPO

Mouse TPO

TPO stands for thrombopoietin, also termed thrombopoiesis stimulating factor (TSF). Mouse TPO is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse TPO may be used for a variety of applications, including:
  • Megakaryocyte proliferation and differentiation in vitro .
  • In vitro expansion of hematopoietic stem cells.
  • In vitro platelet activation.
  • Apoptosis assays.

Alternative Names

MDGF

Background information

Thrombopoietin (TPO), also known as thrombopoiesis stimulating factor (TSF), is a glycoprotein hormone and the major stimulator of megakaryopoiesis and platelet production. TPO is expressed in liver, kidney, spleen, lung, bone marrow, and brain. The TPO receptor is a product of the proto-oncogene
c-mpl
and displays homology with type I cytokine receptor superfamily members. Analogous to the effect of erythropoietin (EPO), the primary mode of action of TPO is inhibition of apoptosis of its target cells. By contrast, TPO is strongly proapoptotic in the brain and acts as a counterpart of EPO which has neuroprotective properties.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of human MO7e cells
  • research grade: ≥ 1.25×
    10
    6
    U/mg
Product options: 4

Product information

Size
Order no.
Price

Mouse TPO, research grade

  • E. coli
  • For research use only
2 µg
130-094-082
-

Mouse TPO, research grade

  • E. coli
  • For research use only
10 µg
130-094-083
-

Mouse TPO, research grade

  • E. coli
  • For research use only
100 µg
130-096-301
-

Mouse TPO, research grade

  • E. coli
  • For research use only
1000 µg
130-108-958
-