Mouse RANK-Ligand – soluble

Mouse RANK-Ligand – soluble

RANK-Ligand stands for receptor activator of NF-κB ligand, also termed TNSFSF11 or TRANCE. Mouse RANK-Ligand is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse RANK-Ligand – soluble can be used for a variety of applications, including:
  • In vitro differentiation of monocytes to osteoclasts, together with M-CSF.
  • Study of cell-receptor signaling of tumor necrosis factor receptor family.
  • Investigation in immune cell activation, osteogenesis, and tumor growth.

Alternative Names

TNFSF11

Background information

Receptor activator of nuclear factor kappa-B (RANK) ligand, also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), together with RANK, is a member of the TNF superfamily of ligands and receptors involved in activation of immune response and in bone regeneration. RANK-Ligand is expressed in several tissues and cell types, including fibroblasts, T cells, and osteoblasts, and functions by binding its cell surface signaling receptor RANK. RANK-Ligand is expressed by T helper cells and is involved in dendritic cell maturation. Binding of osteoprotegerin (OPG) by RANK-Ligand inhibits osteoclastogenesis and leads to accumulation of bone and cartilage. High expression of RANK-Ligand is observed during degenerative bone diseases and in tumors. Mouse RANK-Ligand shares with human 85% amino acid identity.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Induction of osteoclast formation in RAW264.7 cells
Product options: 3

Product information

Size
Order no.
Price

Mouse RANK-Ligand – soluble, research grade

  • E. coli
  • For research use only
2 µg
130-094-645
-

Mouse RANK-Ligand – soluble, research grade

  • E. coli
  • For research use only
10 µg
130-094-076
-

Mouse RANK-Ligand – soluble, research grade

  • E. coli
  • For research use only
100 µg
130-094-646
-