Mouse Noggin

Mouse Noggin

Mouse Noggin is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse Noggin can be used for a variety of applications, including:
  • ES/ iPS differentiation into neural stem cells and retinal cells.
  • Differentiation of endodermal progenitors.
  • Induction of adipogenic differentiation of MSCs.
  • Induction of cardiomyocyte differentiation of mouse ES cells.

Background information

Noggin is a disulfide-linked homodimer that acts by binding members of the TGF-β family, and consequently blocks their ability to signal through their receptors. Noggin plays a crucial role in regulating developmental processes by inhibiting the signaling pathway of bone morphogenetic protein 4 (BMP-4), as well as other BMPs. During embryogenesis Noggin is produced by the dorsal mesoderm and is important for the correct bone morphology and neural tissue formation. Mutations in the Noggin-coding gene (NOG) are associated with several bone diseases. The sequence of Noggin protein shows high homology across several species.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Inhibition of BMP-4–induced alkaline phosphatase production
  • research grade: ≥ 5×
    10
    5
    U/mg
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