Mouse M-CSF

Mouse M-CSF

M-CSF stands for macrophage-colony stimulating factor. Mouse M-CSF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse M-CSF can be used for a variety of applications, including:
  • Generation of bone marrow-derived macrophages.
  • Differentiation of osteoclasts.
  • Proliferation and apoptosis assays.

Background information

Macrophage-colony stimulating factor (M-CSF), a four α-helical bundle cytokine, is a potent hematopoietic regulator. It is primarily produced by monocytes, granulocytes, endothelial cells, and fibroblasts. The main function of M-CSF is the regulation of proliferation, differentiation, and survival of monocytes, macrophages and their hematopoietic progenitors. Furthermore, M-CSF has been shown to play an important role in immunological defense, bone metabolism, fertility, and pregnancy.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of M-NFS-60 cells
  • premium grade: ≥ 2×
    10
    5
    U/mg
  • research grade: ≥ 1×
    10
    5
    U/mg
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