Mouse IL-22

Mouse IL-22

IL-22 stands for interleukin 22, also termed IL-10-related T cell-derived inducible factor (IL-TIF). Mouse IL-22 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-22 may be used for a variety of applications, including:
  • In vitro stimulation of keratinocytes, hepatocytes, and macrophages.
  • Migration and proliferation assays, e.g., in the context of wound healing and tissue regeneration.
  • Investigation of IL-22–mediated signaling pathways.

Background information

Interleukin 22 (IL-22), also known as IL-10–related T cell–derived inducible factor (IL-TIF), is a member of the IL-10 family which consists of potent mediators of cellular inflammatory response. IL-22 is expressed by innate and adaptive immune cells, including NK cells, lymphoid tissue inducer-like cells, T
H
17 cells, and T
H
22 cells. IL-22 acts directly on non-hematopoietic cells. It induces its signals through a two-component receptor comprised of IL-22R1 and IL10Rβ, belonging to the class II cytokine receptor family. The receptor is expressed only on the surface of epithelial cells and some fibroblasts in organs like the gut, lung, skin, and liver. IL-22 has been shown to act cooperatively with IL-17A and IL-17F to enhance expression of acute-phase proteins. Members of the IL-10 family show partial homology in their amino acid sequences, but show distinct biological functions. Human and mouse IL-22 proteins share 81% amino acid identity.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Induction of IL-10 secretion
  • research grade: ≥ 2×
    10
    6
    U/mg
Product options: 3

Product information

Size
Order no.
Price

Mouse IL-22, research grade

  • E. coli
  • For research use only
2 µg
130-096-298
-

Mouse IL-22, research grade

  • E. coli
  • For research use only
10 µg
130-096-283
-

Mouse IL-22, research grade

  • E. coli
  • For research use only
100 µg
130-108-955
-