Mouse IL-2 IS

Mouse IL-2 IS

IL-2 IS stands for interleukin 2 “improved sequence”. Mouse IL-2 IS is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-2 IS can be used for a variety of applications, including:
  • In vitro activation and propagation of mouse T cells, e.g., using the T Cell Activation/Expansion Kit, mouse.
  • In vitro activation and expansion of NK cells.
  • Generation of lymphokine-activated killer (LAK) cells.

Background information

Interleukin 2 (IL-2), a potent lymphoid cell growth factor, is a typical four α-helix bundle cytokine. IL-2 is produced by activated T cells, especially the CD4
+
T helper cell population. It plays an important role in both the activation and maintenance of immune responses and in lymphocyte development. IL-2 promotes proliferation and differentiation of T cells, NK cells, and B cells and is involved in the elimination of self-reactive T cells. IL-2 signals through a receptor complex consisting of IL-2 receptor α-chain (CD25), β- and common γ-chain. The later two are also used for IL-15 signaling.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.
Premium-grade
cytokines offer the convenience of high and well-defined biological activities and allow exact unit dosing for demanding applications. The biological activity is determined after lyophilization and reconstitution, and normalized to WHO/NIBSC standards whenever available. In general, endotoxin levels are <0.01 ng/μg (<0.1 EU/μg), and purities are >97%. Lot-specific certificates of analysis are available on request (macstec@miltenyibiotec.de).

Biological activity

  • Proliferation of mouse CTLL-2 cells
  • premium grade: ≥ 2×
    10
    7
    U/mg
    (typical activity: ≥ 2×
    10
    7
    U/mg
    )
  • research grade: ≥ 8×
    10
    6
    U/mg
Product options: 5

Product information

Size
Order no.
Price

Mouse IL-2 IS, research grade

  • E. coli
  • For research use only
10 µg
130-120-330
-

Mouse IL-2 IS, research grade

  • E. coli
  • For research use only
25 µg
130-120-662
-

Mouse IL-2 IS, premium grade

  • E. coli
  • For research use only
10 µg
130-120-331
-

Mouse IL-2 IS, premium grade

  • E. coli
  • For research use only
25 µg
130-120-332
-

Mouse IL-2 IS, premium grade

  • E. coli
  • For research use only
100 µg
130-120-333
-