Mouse IL-1β

Mouse IL-1β

IL-1β stands for interleukin 1β, also termed catabolin or IFN-β inducing factor. Mouse IL-1β is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-1β can be used for for a variety of applications including:
  • Activation of antigen-presenting cells
  • Polarization of TH 17 cells
  • Investigation of IL-1 receptor signaling

Alternative Names

IL-1F2, Catabolin, MCF

Background information

Interleukin 1β (IL-1β) is a proinflammatory cytokine secreted mainly by monocytes and macrophages. IL-1β secretion has also been reported for a variety of other cells, including B cells, NK cells, dendritic cells, astrocytes, and microglial cells. It mediates inflammatory responses in B cells, T cells, and NK cells by inducing the production of cytokines, such as IL-2, IL-3, IL-6, as well as interferons. Upon exposure to IL-1β, endothelial cells and smooth muscle cells synthesize prostaglandins and other derivatives of arachidonic acid. In addition, during arthritic diseases, IL-1β causes degranulation of basophils and eosinophils as well as activation of osteoclasts. IL-1β is mitogenic for mesangial cells, glial cells, and keratinocytes.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.
Premium-grade
cytokines offer the convenience of high and well-defined biological activities and allow exact unit dosing for demanding applications. The biological activity is determined after lyophilization and reconstitution, and normalized to WHO/NIBSC standards whenever available. In general, endotoxin levels are <0.01 ng/μg (<0.1 EU/μg), and purities are >97%. Lot-specific certificates of analysis are available on request (macstec@miltenyibiotec.de).

Biological activity

  • Proliferation of D10.G4.1 cells (NIBSC 93/668)
  • premium grade: ≥ 8×
    10
    8
    U/mg
  • research grade: ≥ 5×
    10
    8
    U/mg
Product options: 6

Product information

Size
Order no.
Price

Mouse IL-1β, research grade

  • E. coli
  • For research use only
10 µg
130-094-053
-

Mouse IL-1β, research grade

  • E. coli
  • For research use only
25 µg
130-101-680
-

Mouse IL-1β, premium grade

  • E. coli
  • For research use only
10 µg
130-101-681
-

Mouse IL-1β, premium grade

  • E. coli
  • For research use only
25 µg
130-101-682
-

Mouse IL-1β, premium grade

  • E. coli
  • For research use only
100 µg
130-101-683
-

Mouse IL-1β, premium grade

  • E. coli
  • For research use only
1000 µg
130-101-684
-