Mouse IL-1α

Mouse IL-1α

IL-1α stands for interleukin 1α. Mouse IL-1α is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-1α can be used for a variety of applications including:
  • In vitro stimulation of Tʜ cells.
  • Proliferation of lymphocytes.
  • Chemotactic assays.

Background information

IL-1α is a monomeric protein belonging to the IL-1 family which also comprises interleukin-1β (IL-1β). Both IL-1α and IL-1β bind to the same receptor and therefore also show similar if not identical biological activities. A key function of IL-1α and IL-1β is the stimulation of T helper (Tʜ) cells by inducing IL-2 release. Furthermore, IL-1 is involved in B cell maturation and proliferation and has fibroblast growth factor activity. IL-1, in combination with other cytokines, plays a significant role in the the development of inflammatory responses. IL-1α is the predominant IL-1 form in mouse. In mice, a transition from IL-1β to IL-1α production during maturation of monocytes into inflammatory macrophages can be observed. Murine Tʜ17 cells develop in response to IL-1 and other cytokines.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Stimulation of murine D10S cells
  • research grade: ≥ 5×
    10
    8
    U/mg
Product options: 2

Product information

Size
Order no.
Price

Mouse IL-1α, research grade

  • E. coli
  • For research use only
2 µg
130-094-050
-

Mouse IL-1α, research grade

  • E. coli
  • For research use only
10 µg
130-094-051
-