Mouse IL-17F

Mouse IL-17F

IL-17F stands for interleukin 17F. Mouse IL-17F is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-17F can be used for a variety of applications, including:
  • Chemotactic assays.
  • Activation of macrophages and neutrophils.
  • In vitro models of inflammation and allergy.

Background information

Interleukin 17A (IL-17A) is the founding member of the IL-17 family, which is composed of six members with different patterns of expression. The IL-17 family is characterized by a common disulfide-linked homodimeric structure, and different family members can also form heterodimers, such as IL-17A/IL-17F. IL-17 family members act as pro-inflammatory agents involved in the immunity against extracellular pathogens, but they are extensively studied mainly for their pathogenic role in autoimmunity and allergy. IL-17F is expressed by Th17 cells, NK cells, monocytes, basophils and mast cells, and plays a chemotactic role for neutrophils. Both IL-17A and IL-17F act on a specific receptor complex formed by IL-17RA and IL-17RC, expressed on different stromal cells in several tissues, such as endothelial cells, fibroblasts, and immune cells. IL-17F also plays a regulatory role as inhibitor of angiogenesis, and participates in the regulation of cartilage matrix modeling. A strong association between IL-17F and asthma has been found, and IL-17F is investigated as therapeutic target for the cure of allergic airway inflammation.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.
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