Mouse IL-10

Mouse IL-10

IL-10 stands for interleukin 10. Mouse IL-10 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-10 can be used for a variety of applications including:
  • In vitro inhibition of inflammatory cytokine production.
  • In vitro induction of proliferation and differentiation, in synergy with IL-4.

Background information

IL-10 is a homodimeric cytokine mainly produced by CD4
+
Tʜ2 cells, regulatory T cells (Treg), Ly-1 B cells, and keratinocytes. IL-10 is regarded as a regulator of the development of Ly-1 B cells and inhibits the synthesis and secretion of many cytokines. Expression of IL-10 in the islets of Langerhans cells of transgenic mice has been shown to lead to a pronounced inflammation of the pancreas. Knockout mice lacking IL-10 are growth retarded, anemic, and suffer from chronic local bowel inflammations. Like IL-4, it enhances the humoral immune response and lessons cell mediated immune reactions. Mouse IL-10 shares 73% amino acid sequence homology with human IL-10 and is able to block the binding of human IL-10 to mouse cells but not to human cells.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of mouse MC/9 cells
  • research grade: ≥ 5×
    10
    5
    U/mg
Product options: 2

Product information

Size
Order no.
Price

Mouse IL-10, research grade

  • E. coli
  • For research use only
2 µg
130-094-067
-

Mouse IL-10, research grade

  • E. coli
  • For research use only
10 µg
130-094-068
-