Mouse IFN-α

Mouse IFN-α

IFN-α stands for interferon alpha. Mouse IFN-α is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IFN-α can be used for a variety of applications including:
  • In vitr o investigation of antitumor effects, such as antiproliferative capacities, on tumor cell lines.
  • Studies on signal transduction and gene expression on cell lines.
  • In vivo investigation of anti-tumor effects in mouse models of disease.
  • Studies of transgenic mice harboring the Cre-recombinase transgene driven by the interferon-inducible Mx promoter (Mx-Cre mice).

Background information

Type I interferons (IFNs), including IFN-α, are a family of cytokines that exert multiple functions in the immune system. The most prominent effect of IFN-α is its antiviral activity. Upon viral infections, host cells release IFN-α, which can act in an autocrine or paracrine manner to activate intracellular antiviral defense mechanisms and restrict viral replication. Furthermore, IFN-α affects the generation and function of various dendritic cell populations. Immunomodulatory activity and antitumor effects have been described both
in vivo
and
in vitro
.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Inhibition of BW cells
  • research grade: ≥ 5×
    10
    7
    IU/mL
Product options: 2

Product information

Size
Order no.
Price

Mouse IFN-α, research grade

  • HEK293 cells
  • For research use only
200 µL
130-093-131
-

Mouse IFN-α, research grade

  • HEK293 cells
  • For research use only
1 mL
130-093-130
-