Mouse Gro-α/KC

Mouse Gro-α/KC

Mouse Gro-α/KC is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse GRO-α/KC can be used for a variety of applications, including:
  • Investigation of development of chronic inflammation diseases.
  • Activation of neutrophils.
  • Chemotactic assays.

Alternative Names

CXCL1

Background information

Keratinocyte chemoattractant (KC), also called CXCL1, belongs to the family of alpha (CXC) chemokines and is suggested to be the homolog of human Gro-α. Gro-α/KC is an important chemoattractant and activating factor for neutrophils. Besides its recognized role in inflammation and angiogenesis, it shows antimicrobial effects. KC is expressed in mouse fibroblasts, macrophages, and endothelial cells and CXCR2 has been identified as its functional receptor. It has been shown that KC plays a critical role in the development of experimental Lyme arthritis and carditis in mice (Ritzman et al).

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Mobilization of intracellular calcium of human neutrophils
Product options: 2

Product information

Size
Order no.
Price

Mouse Gro-α/KC, research grade

  • E. coli
  • For research use only
5 µg
130-094-045
-

Mouse Gro-α/KC, research grade

  • E. coli
  • For research use only
20 µg
130-094-046
-