Human SCF

Human SCF

SCF stands for stem cell factor, also termed c-kit ligand, mast cell growth factor (MGF), or steel factor (SLF). Human SCF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.


Human SCF can be used for a variety of applications, including:
  • Stimulation of proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures.
  • In vitro expansion of CD34+ hematopoietic progenitor cells.
  • Differentiation of ES-derived cells towards the hematopoietic lineage.
  • Mast cell differentiation and maintenance.
  • Mast cell chemotaxis assays.

Alternative Names

c-kit ligand, steel factor, MGF

Background information

SCF is a hematopoietic growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and progenitor cells. Besides its pivotal role in mast cell development, SCF acts as a potent mast cell chemoattractant and upregulates mast cell adhesion and migration. SCF signals through the c-kit receptor (CD117) and exists in two forms; cell surface bound SCF and soluble SCF. The secreted soluble form of SCF is produced by the proteolytic processing of the cell surface anchored precursor molecule.

Quality description

cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.
cytokines offer the convenience of high and well-defined biological activities and allow exact unit dosing for demanding applications. The biological activity is determined after lyophilization and reconstitution, and normalized to WHO/NIBSC standards whenever available. In general, endotoxin levels are <0.01 ng/μg (<0.1 EU/μg), and purities are >97%. Lot-specific certificates of analysis are available on request (

Biological activity

  • Proliferation of TF-1 cells (NIBSC 91/682)
  • premium grade: ≥ 4×
    (typical activity: ≥ 9×
  • research grade: ≥ 2×

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