Human R-Spondin 1

Human R-Spondin 1

R-Spondin 1 stands for roof plate-specific spondin-1. Human R-Spondin 1 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human R-Spondin 1 can be used for a variety of applications including:
  • Stimulation of adult stem cell proliferation in vitro and in vivo .
  • Investigation of embryonic development and tissue differentiation.
  • Study of the canonical Wnt/β-catenin signaling pathway.

Alternative Names

F-spondin

Background information

R-Spondin-1, also known as Rspo-1, is a growth factor belonging to the R-Spondin family. R-Spondins are four proteins that support adult stem cell proliferation, and act as Wnt modulators by signaling through the canonical Wnt/β-catenin pathway as agonists. LGR4, LGR5, and LGR6 have been identified as receptors for all four R-Spondins. R-Spondin 1 is expressed in the nervous system during development and in endocrine tissues, especially in the gonads. It potentiates the signaling of Wnt-4 and antagonizes DKK-1 activity, and is crucial for the formation of female phenotype by opposing male phenotype development. R-Spondin 1 is also involved in the control of keratin formation, in the induction of cell proliferation in mucosal tissues, and in the inhibition of pro-inflammatory processes.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Differentiation of MC3T3-E1 cells in presence of BMP-2
  • research grade: ≥ 0.3×
    10
    3
    U/mg
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