Human NT-3

Human NT-3

NT-3 stands for neurotrophin 3, also termed hippocampus-derived neurotrophic factor (HDNF). Human NT-3 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human NT-3 may be used for a variety of applications, including:
  • In vitro stimulation of endothelial cell survival.
  • Proangiogenic capacity in vitro .
  • Survival and differentiation factor in neuronal cell culture.
  • Investigation of Trk signaling.
  • Stimulation of axon outgrowth in vitro .

Alternative Names

NTF-3, HDNF

Background information

Neurotrophin 3 (NT-3), also known as hippocampus-derived neurotrophic factor (HDNF), is a member of the neurotrophin family. It shares high structural homology to nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 4 (NT-4), but they all operate via different high-affinity membrane receptors and differ in target specificity. Expression of NT-3 has been detected in neurons of the central nervous system like the hippocampus and cerebellum. Furthermore it is expressed in muscles. NT-3 promotes the survival and differentiation of existing neurons and supports the growth and differentiation of new nerve and glial cells. It has been shown to bind and activate the TrkC tyrosine receptor kinase. The activities of NT-3 and BDNF are additive in some systems. The amino acid sequence of human and mouse NT-3 is identical.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Induction of choline acetyl transferase activity
  • research grade: ≥ 2×
    10
    4
    U/mg
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