Human MCP-1

Human MCP-1

MCP-1 stands for monocyte chemotactic protein 1, also termed monocyte chemotactic and activating factor (MCAF) or CCL2. Human MCP-1 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human MCP-1 can be used for a variety of applications, including:
  • Chemotactic assays.
  • Inflammation studies.

Alternative Names

CCL2, MCAF

Background information

MCP-1 belongs to the CC chemokine subfamily and is also known as CCL2. It signals predominantly through CCR2. MCP-1 is expressed by various cell types and besides monocyte and tissue macrophages also attracts T cells and NK cells to sites of inflammation. In addition to chemotaxis further pro-inflammatory activities, such as all activation, angiogenesis, and fibrosis are attributed to MCP-1.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Chemotaxis of human peripheral blood monocytes
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