Human IL-8 (72 aa)

Human IL-8 (72 aa)

IL-8 stands for interleukin 8. Human IL-8 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-8 (72 aa) can be used for a variety of applications, including:
  • Study of leukocyte chemotaxis.
  • Investigation of CXCR1 and CXCR2 signaling pathway.

Alternative Names

CXCL8

Background information

Interleukin 8 (IL-8), also known as CXCL8, is a proinflammatory molecule belonging to the CXC chemochine family. The precursor form of IL-8 is cleaved into several mature isoforms (including 72 aa and 77 aa) and is secreted by several type of cells, especially monocytes and endothelial cells, upon pro-inflammatory stimulation. IL-8 signals through the CXCR1 and CXCR2 receptors, chemoattracts and activates granulocytes, especially neutrophils and lymphocytes, and plays also an angiogenic role. Overexpression of IL-8 can lead to epithelial damage and injury of the airway tissues.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Chemotaxis of human peripheral blood neutrophils
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