Human IL-5

Human IL-5

IL-5 stands for interleukin 5. Human IL-5 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-5 can be used for a variety of applications including:
  • Cultivation and differentiation of eosinophils.
  • Investigation on allergies, parasitic infections, and tumors.

Background information

Interleukin 5 (IL-5), also known as eosinophil differentiation factor (EDF) or eosinophil colony stimulating factor (Eo-CSF), belongs to the hematopoietic family of cytokines, together with IL-3 and GM-CSF, whose receptors share the common-cytokine-receptor β-chain. IL-5 is secreted by T helper cells, mast cells, and eosinophils and mainly acts as a key hematopoietic growth factor for the proliferation and activation of eosinophils, but also promotes the secretion of immunoglobulins by B cells, and the generation of cytotoxic T cells. Through the activation of eosinophils, IL-5 mediates several allergic diseases, but it is also involved in parasitic infections and tumor development.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of human TF-1 cells
  • research grade: ≥ 5×
    10
    6
    U/mg
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