Human IL-34

Human IL-34

IL-34 stands for interleukin 34. Human IL-34 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-34 can be used for a variety of applications including:
  • In vitro studies of monocyte, macrophage, and dendritic cell differentiation.
  • Developmental studies of bone marrow and CNS.
  • Investigation of CSFR1 signaling.

Background information

Interleukin 34 (IL-34) is a four helical homodimeric protein that does not belong to any already identified cytokine family. It is expressed by several different tissues upon inflammatory stimuli. Notably, IL-34 shares structural homology with M-CSF and signals via the colony stimulating factor (CSF) receptor 1, and induces myeloid cell expansion and differentiation, similarly to other CSF (G-CSF, M-CSF, and GM-CSF). IL-34 promotes survival of monocytes and proliferation of macrophages, and plays a hematopoietic differentiation role in the bone marrow, inducing colony forming units of macrophages and promoting osteoclast differentiation, adhesion, and proliferation. A role of IL-34 in the development of myeloid compartments, especially dendritic cells and monocyte, but also Langerhans cells and microglia, is under investigation. Mouse IL-34 shares 71% protein sequence identity with human IL-34.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Secretion of MCP-1 from PBMCs
  • research grade: ≥ 0.1×
    10
    3
    U/mg
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