Human IL-23

Human IL-23

IL-23 stands for interleukin 23. Human IL-23 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-23 can be used for a variety of applications, including:
  • In vitro differentiation of CD4+ T cells towards TH 17 cells and proliferation of TH 17 cells.
  • Exploration of the role of IL-23 in autoimmune diseases or inflammatory bowel diseases.
  • Investigation of IL-23–mediated molecular signaling pathways.

Background information

Interleukin 23 (IL-23) is a covalently linked heterodimeric cytokine, which is closely related to IL-12. Macrophages and dendritic cells (DCs) are the major sources of both IL-12 and IL-23, which act on receptors primarily expressed by T cells, NK cells, and NKT cells. IL-23 consists of the p40 subunit shared with IL-12 (IL-12B, IL-12 p40, IL-23 p40) and the 19 kDa protein p19 (IL-23 p19, IL-23A). Its effects are mediated by a receptor composed of IL-12 receptor subunit B1 and an IL-23 specific subunit. While IL-12 drives the development of T
H
1 cells, IL-23 mediates the full differentiation and maintenance of T
H
17 cells. IL-23 stimulates memory CD4
+
rather than naive T cells and promotes the production of pro-inflammatory cytokines. As a key cytokine in the survival and proliferation of T
H
17 cells, IL-23 has central roles in autoimmune diseases and promotes chronic inflammation. It has been shown that single chain fusion proteins of naturally heterodimeric cytokines such as IL-12 or IL-23 are bioactive
in vitro
and
in vivo
.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Induction of IFN-γ secretion by human PBMCs
  • research grade: ≥ 1×
    10
    5
    U/mg
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