Human IL-1α

Human IL-1α

IL-1α stands for interleukin 1α. Human IL-1α is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-1α can be used for a variety of applications including:
  • Proliferation of lymphocytes.
  • Chemotaxis assays.
  • Investigation of IL-1 receptor signaling.

Background information

Interleukin 1 alpha (IL-1α) is a cytokine that participates in the regulation of immune responses, inflammatory reactions, and hematopoiesis. IL-1α is produced mainly by activated macrophages as well as neutrophils, epithelial cells, and endothelial cells. It is involved in lymphocyte proliferation, inducing IL-2 release, B cell maturation and proliferation, and immunoglobulin secretion. In addition, it also plays a role in fibroblasts proliferation.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of mouse D10S cells
  • research grade: ≥ 1×
    10
    8
    U/mg
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