Human IL-11

Human IL-11

IL-11 stands for interleukin 11. Human IL-11 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-11 can be used for a variety of applications, including:
  • Megakaryocyte colony formation assay (in combination with IL-3).
  • Differentiation of erythroid progenitors (in combination with IL-3 and SCF).
  • Culture of primitive hematopoietic precursors (in combination with IL-4).
  • Osteoclast differentiation and maturation.

Background information

Interleukin 11 (IL-11) is a multifunctional cytokine member of the IL-6 family. It is found in different organs and tissues and it is secreted by mesenchymal cells including fibroblasts, stromal cells, osteoclasts and epithelial cells. IL-11 receptor is an heterodimeric protein that is expressed by different hematopoietic lineages such as megakaryocyte, erythroid, and myeloid progenitors. In combination with other cytokines (IL-4, IL-3, and SCF), IL-11 regulates several hematopoiesis processes, including megakaryocyte maturation. IL-11 activates certain B and T cells and has a role in primary and secondary immune responses as modulator of auto-inflammation in favor of Th2 polarization and allergic reactions. In addition, IL-11 participates in the regulation of osteoclast differentiation and blastocyst implantation. IL-11 is under investigation for the treatment of osteoporosis, thrombocytopenia, and inflammatory conditions.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of human MO7e cells
  • research grade: ≥ 1×
    10
    5
    U/mg
Product options: 3

Product information

Size
Order no.
Price

Human IL-11, research grade

  • E. coli
  • For research use only
2 µg
130-094-623
-

Human IL-11, research grade

  • E. coli
  • For research use only
10 µg
130-093-950
-

Human IL-11, research grade

  • E. coli
  • For research use only
100 µg
130-103-439
-