Human HGF

Human HGF

HGF stands for hepatocyte growth factor. Human HGF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human HGF can be used for a variety of applications, including:
  • In vitro culture and expansion of hepatocytes.
  • Proliferation and migration of epithelial cells.
  • Tissue development, regeneration and organogenesis.
  • Angiogenesis and tumor cell culture.
  • Colony formation of hematopoietic progenitors.

Alternative Names

HPTA, SF

Background information

Hepatocyte growth factor (HGF) is a multifunctional polypeptide secreted by mesenchymal cells, in the liver and in the epithelium of several tissues. During tissue damage, the biological inactive single chain precursor is cleaved by specific extracellular serine proteases, into a fully active disulfide-linked heterodimer. Activation of the HGF signalling pathway induces proliferation, migration and morphogenesis of different cell types during several processes of tissue growth and differentiation. These processes include hepatic growth and endothelial proliferation, but also embryonic development, angiogenesis, tumorigenesis and metastatization. In presence of inflammatory stimulation, such as IL-6 and TNF-α, HGF acts as growth factor for hepatocytes, and mediates an anti-inflammatory response. HGF is also involved in hematopoiesis in combination with IL-3 and GM-CSF. Because of its key role as mitogen and regulator of tissue development, recombinant HGF is under investigation for clinical applications in the cure of liver and vascular diseases. HGFs of different species share very similar functions and high homologies. Recombinant Human HGF corresponds to the fully active disulfide-linked heterodimer.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Scattering activity in the MDCK cell assay
  • research grade: ≥ 2×
    10
    5
    U/mg
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