Human FGF-4

Human FGF-4

FGF-4 stands for fibroblast growth factor 4. Human FGF-4 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human FGF-4 can be used for a variety of applications, including:
  • Promotion of embryonic stem cell proliferation and differentiation.
  • Culture of fibroblast and epithelial cells and investigation of angiogenesis.
  • Study of FGFR and SHH signaling pathways.

Alternative Names

HBGF-4

Background information

Fibroblast growth factor 4 (FGF-4) is a heparin-binding growth factor and member of the FGF family, which controls several physiological and pathological development processes, including cell growth, cell survival, and morphogenesis. FGF-4 is expressed during embryo development and in several tissues during the adult life, and binds both receptors FGFR 1c, 2c, 3c, and 4. FGF-4 function partially overlaps with the one of FGF-8. By promoting cell differentiation, FGF-4 plays a central role during prenatal development and tissue regeneration, but can also have a pathological role as oncogene in tumor growth. Increased levels of FGF-4 was found in several human tumors. Altered levels of FGF-4 during embryo development can result in abnormal limb formation. Mature human FGF-4 shares 86% amino acid identity with mouse FGF-4.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of mouse 3T3 cells
  • premium grade: ≥ 1×
    10
    6
    U/mg
  • research grade: ≥ 5×
    10
    5
    U/mg
Product options: 6

Product information

Size
Order no.
Price

Human FGF-4, research grade

  • E. coli
  • For research use only
10 µg
130-109-387
-

Human FGF-4, research grade

  • E. coli
  • For research use only
25 µg
130-109-388
-

Human FGF-4, premium grade

  • E. coli
  • For research use only
10 µg
130-109-389
-

Human FGF-4, premium grade

  • E. coli
  • For research use only
25 µg
130-109-390
-

Human FGF-4, premium grade

  • E. coli
  • For research use only
100 µg
130-109-394
-

Human FGF-4, premium grade

  • E. coli
  • For research use only
1000 µg
130-109-391
-