Human CTGF

Human CTGF

CTGF stands for Connective Tissue Growth Factor. It is also known as CCN2 or hypertrophic chondrocyte-specific protein 24 (HCS24). Human CTGF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human CTGF can be used for a variety of applications including:
  • Chondrocyte proliferation and differentiation.
  • Fibroblast differentiation.
  • Spinal cord regeneration.

Background information

Connective tissue growth factor (CTGF) is a member of the CCN family and involved in cell adhesion of fibroblasts, migration, proliferation, and angiogenesis. It is produced by the umbilical vein, vascular endothelial cells, and glial cells. CTGF is also involved in fibrotic disease and several forms of cancers. In zebrafish it was shown that CTGF is involved in spinal cord repair.
CTGF comprises four different domains. An insulin-like growth factor (IGF)-binding domain, a von Willebrand type C (VWC) domain, a thrombospondin-1 (TSP-1) domain, and a C-terminal cystine knot-like domain. The individual domains can regulate different cellular functions and certain domains can act interdependently.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of HUVEC cells
  • research grade: ≥ 0.5×
    10
    3
    U/mg
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