Human BMP-6

Human BMP-6

BMP stands for bone morphogenetic protein. Human BMP-6 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human BMP-6 can be used for a variety of applications, including:
  • MSC differentiation to osteoblasts.
  • Chondrocyte maturation.

Background information

Bone morphogenetic protein 6 (BMP-6) is a member of the bone morphogenetic protein family, which is part of the TGF-β superfamily. BMP-6 plays an important role in embryogenesis, tissue morphogenesis, and cell differentiation and migration. It can signal through various receptor complexes inducing SMAD signaling and other processes. Differential expression of BMP-6 may be associated with progression of breast and prostate cancer.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Alkaline phosphatase production by ATDC-5 cells.
  • research grade: ≥ 3.3×
    10
    4
    U/mg
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