GadoSpin M

GadoSpin M

GadoSpin M is a gadolinium-based contrast agent of low molecular weight specifically formulated for pre-clinical magnetic resonance imaging (MRI).
GadoSpin M increases the signal intensity in T1-weighted MRI due to a shortening of the spin-lattice relaxation time (T1).
Upon intravenous injection, GadoSpin M is rapidly distributed in the extracellular space. No significant plasma protein–binding can be observed and the stable complex is excreted unchanged via glomerular filtration (kidneys) within hours.
Gd-DTPA does not penetrate the intact blood brain barrier and is, in fact, used in clinical practice for imaging of brain tumors.

Applications

GadoSpin M is indicated for use in MRI of small animals, for example, mice to facilitate the visualization of the extracellular space.
Examples include disruption of the blood brain barrier and fenestration of blood vessels in inflamed tissue or tumors.
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