MACS GMP Recombinant Human IL-7

MACS GMP Recombinant Human IL-7

Interleukin 7 (IL-7) is a pleiotropic cytokine with central roles in modulating T cell development and peripheral T cell homeostasis. IL-7 can act both as a T cell growth factor as well as a critical anti-apoptotic survival factor for naive and memory T cells.
MACS GMP Recombinant Human IL-7 is designed for
ex vivo
cell culture processing. No animal- or human-derived materials were used for the manufacture of this product, unless otherwise stated in the respective Certificate of Origin. The product is lyophilized without carrier protein or preservatives.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

The primary sources of IL-7 are non-hematopoietic stromal cells in bone marrow, thymus, and lymphoid organs and tissues. IL-7 is a member of the type I cytokine family. It is related to IL-2 and signals through a heterodimeric receptor composed of the common cytokine signaling γ-chain and IL-7 receptor α-chain.

Applications

MACS GMP Recombinant Human IL-7 can be used for a variety of applications, including the
ex vivo
generation of antigen-specific cytotoxic T lymphocytes.
2,3

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Biological activity

  • The specific activity is determined by proliferation assay according to Ishihara
    et al.1
    using mouse 2E8 cells. The proliferation assay was calibrated with the reference standard for human IL-7 (NIBSC code 90/530) provided by the National Institute for Biological Standards and Control.
  • Specific activity: ≥ 5×
    10
    7
    U/mg
Product options: 1

Product information

Size
Order no.
Price

MACS GMP Recombinant Human IL-7

  • E. coli
  • For research use and
    ex vivo
    cell processing only
25 µg
170-076-111
-