MACS GMP Recombinant Human IL-1β

MACS GMP Recombinant Human IL-1β

Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that mediates inflammatory responses and displays a wide variety of biological activities on many different cell types, including T cells, B cells, and monocytes.
MACS GMP Recombinant Human IL-1β is designed for
ex vivo
cell culture processing. No animal- or human-derived materials were used for the manufacture of this product, unless otherwise stated in the respective Certificate of Origin. The product is lyophilized without carrier protein or preservatives.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

IL-1β is mainly secreted by monocytes and macrophages. IL-1β secretion has also been reported for a variety of other cells, including B cells, NK cells, dendritic cells, astrocytes, and microglial cells. IL-1β acts also on nonimmune system cells such as fibroblasts, vascular endothelial cells, and hepatocytes.

Applications

MACS GMP Recombinant Human IL-1β can be used for a variety of applications, including the
ex vivo
generation of human dendritic cells from enriched CD14
+
monocyte populations.
2–4

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Biological activity

  • The specific activity is determined by proliferation assay according to Poole and Gaines-Das
    1
    using D10.G4.1 cells provided by the German Resource Centre for Biological Material (DSMZ). The proliferation assay was calibrated with the first international reference standard for human IL-1β (NIBSC code 86/680) provided by the National Institute for Biological Standards and Control.
  • Specific activity: ≥ 2×
    10
    7
    IU/mg
  • Certificates of Analysis (CoA)

    Please follow this
    link
    to search for certificates by lot number.
Product options: 1

Product information

Size
Order no.
Price

MACS GMP Recombinant Human IL-1β

  • E. coli
  • For research use and
    ex vivo
    cell processing only
25 µg
170-076-102
-